FASTGAS FOR DUMMIES

The final proposed mechanism of RBC vasodilation within the existence of nitrite may be the reduction of nitrite to NO by Hb. Brooks very first examined the nitrite Hb interaction in 1937 which operate was later extended by Doyle in 1981 (Brooks, 1937; Doyle et al., 1981). Nitrite reacts with deoxygenated Hb to form metHb and NO (Brooks, 1937; Doyl